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How do people stop using substances once they have become addicted to them? The neuroscientist Roy Wise, who studies addiction in animals, says that the only way an addicted animal will stop using drugs is if the drug is no longer available, the animal is too physically exhausted to administer the drug, or the animal dies. 17 Humans are clearly different from animals, and complex psychological, social, and spiritual factors play a role in the decision to initiate as well as to stop using substances.